N-(tert-Butoxycarbonyl)-1,5-diaminopentane → HCID 18470602, compound

HRID 2228473Notes

Reaction equation

HRID 2228473 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[C:17]=1[C:23]1[C:27]([C:28](Cl)=[O:29])=[C:26]([CH3:31])[O:25][N:24]=1>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:28]([C:27]1[C:23]([C:17]2[C:18]([F:22])=[CH:19][CH:20]=[CH:21][C:16]=2[Cl:15])=[N:24][O:25][C:26]=1[CH3:31])=[O:29])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 4352N-(tert-Butoxycarbonyl)-1,5-diaminopentaneHCID 27365813-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride

Product 1

HCID 18470602HCID 18470602, compoundYield 94.6%

Procedure

N-t-butyloxycarbonyl-1,5-diaminopentane (1.04 g, 5.14 mmol) and 3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-oyl chloride (1.41 g, 5.14 mmol) were converted to 2.14 g of the title compound by the procedure of Preparation 1. (95%). MS(IS) m/z 412 (M+). IR(CHCl3) 3496, 3012, 2936, 1708, 1663, 1611, 1510 cm−1.

Sources & evidence

ORD record
ord-c5db2ec4526f489e87720bea3e1151eb
Source dataset
uspto-grants-2002_07
Patent number
US06417193B1

Reaction notes

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