3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride → HCID 18470598, compound

HRID 2228477Notes

Reaction equation

HRID 2228477 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:11])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH2:10].[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=1[C:20]1[C:24]([C:25](Cl)=[O:26])=[C:23]([CH3:28])[O:22][N:21]=1>>[CH3:2][O:3][C:4](=[O:11])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:25]([C:24]1[C:20]([C:14]2[C:15]([F:19])=[CH:16][CH:17]=[CH:18][C:13]=2[Cl:12])=[N:21][O:22][C:23]=1[CH3:28])=[O:26]

Participants

3

Reactant 2

HCID 27365813-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chlorideHCID 11499324Methyl 6-aminohexanoate hydrochloride

Product 1

HCID 18470598HCID 18470598, compoundYield 303.4%

Procedure

Methyl-6-aminohexanoate hydrochloride (349 mg, 1.92 mmol) and 3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-oyl chloride (527 mg, 1.92 mmol) were converted to 2.23 g of the title compound by the procedure of Preparation 10. (100%). EA calculated for: C18H20N2O4ClF: C, 56.48; H, 5.27; N, 7.32. Found: C, 56.66; H, 5.20; N, 7.07. MS(FD) m/z 382.2 (M+).

Sources & evidence

ORD record
ord-b1e83175ac26444da9b57c2a0c0a470a
Source dataset
uspto-grants-2002_07
Patent number
US06417193B1

Reaction notes

Loading…