HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2-Methyl-6-nitro-phenyl)-(4-trifluoromethoxy-phenyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(Trifluoromethoxy)aniline | HCID 600848 | — |
| Reactant | 2-Fluoro-1-methyl-3-nitrobenzene | HCID 13470957 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (2-Methyl-6-nitro-phenyl)-(4-trifluoromethoxy-phenyl)-amine | HCID 68834647 | — |
Reaction Steps
The product (1.92 g) is obtained as a hydrochloride according to the method of stage 1 of Example 4, by using 1 g of 2-fluoro-3-methyl-nitrobenzene and 1.3 mL of 4-trifluoromethoxy-aniline in the presence of 1.16 g of potassium tert-butanolate in 10 mL of DMSO.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207373B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-05e6ab38286f4d8b9b20d98a60da6529 |
| Source note | uspto-grants-2012_06 |