Hydrochloric Acid → (2-Methyl-6-nitro-phenyl)-(4-trifluoromethoxy-phenyl)-amine

HRID 222856Notes

Reaction equation

HRID 222856 reaction equation
Cl.F[C:3]1[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N+:10]([O-:12])=[O:11].[F:13][C:14]([F:24])([F:23])[O:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1.C([O-])(C)(C)C.[K+]>CS(C)=O>[CH3:9][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[NH:20][C:19]1[CH:21]=[CH:22][C:16]([O:15][C:14]([F:13])([F:23])[F:24])=[CH:17][CH:18]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6008484-(Trifluoromethoxy)anilineHCID 134709572-Fluoro-1-methyl-3-nitrobenzeneHCID 23665647Potassium tert-butoxide

Product 1

HCID 68834647(2-Methyl-6-nitro-phenyl)-(4-trifluoromethoxy-phenyl)-amine

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The product (1.92 g) is obtained as a hydrochloride according to the method of stage 1 of Example 4, by using 1 g of 2-fluoro-3-methyl-nitrobenzene and 1.3 mL of 4-trifluoromethoxy-aniline in the presence of 1.16 g of potassium tert-butanolate in 10 mL of DMSO.

Sources & evidence

ORD record
ord-05e6ab38286f4d8b9b20d98a60da6529
Source dataset
uspto-grants-2012_06
Patent number
US08207373B2

Reaction notes

Loading…