Ammonia → HCID 12051826, compound

Participants

Reaction Steps

To a stirred solution of 4-quinolinecarboxaldehyde (2.3 g; 14.8 mmol), 4-pyridinecarboxaldehyde (1.6 g ; 14.8 mmol) in EtOH (40 mL) was added 2,4-pentanedione (2 g; 20 mmol) and 25% aqueous ammonia solution (8 ml) at room temperature. The mixture was heated at reflux temperature for 18 hours. After cooling, volatiles were removed by evaporation. Chromatographic purification of the residue on silica gel eluting with CH2Cl2—EtOH (20:1→8:1) provided 1.1 g, which was recrystallized from EtOH to afford the title compound (0.82 g, 17% yield) as a pale yellow solid.

Provenance & Evidence