HCID 59900611, compound → 2-[3-({[(2R)-1-(tert-butoxycarbonyl)pyrrolidinyl]methyl}amino)-6-methyl-2-oxo-1(2H)-pyrazinyl]acetic acid

HRID 2228752Notes

Reaction equation

HRID 2228752 reaction equation
C([O:8][C:9](=[O:34])[CH2:10][N:11]1[C:16]([CH3:17])=[C:15](Cl)[N:14]=[C:13]([NH:19][CH2:20][C@H:21]2[CH2:25][CH2:24][CH2:23][N:22]2[C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C:12]1=[O:33])C1C=CC=CC=1>[OH-].[Pd+2].[OH-]>[C:29]([O:28][C:26]([N:22]1[CH2:23][CH2:24][CH2:25][C@@H:21]1[CH2:20][NH:19][C:13]1[C:12](=[O:33])[N:11]([CH2:10][C:9]([OH:34])=[O:8])[C:16]([CH3:17])=[CH:15][N:14]=1)=[O:27])([CH3:30])([CH3:31])[CH3:32]

Participants

3

Reactant 1

HCID 59900611HCID 59900611, compound

Product 1

HCID 599006292-[3-({[(2R)-1-(tert-butoxycarbonyl)pyrrolidinyl]methyl}amino)-6-methyl-2-oxo-1(2H)-pyrazinyl]acetic acid

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

The title compound was prepared by a similar method to preparation 44 from tert-butyl (2R)-2-[({4-[2-(benzyloxy)-2-oxoethyl]-6-chloro-5-methyl-3-oxo-3,4-dihydro-2-pyrazinyl}amino)methyl]-1-pyrrolidinecarboxylate [see preparation 53] and palladium hydroxide to afford the product as a white foam, (68%).

Sources & evidence

ORD record
ord-899a78a82ed249f0bb4ce367eeb61de7
Source dataset
uspto-grants-2002_07
Patent number
US06417203B1

Reaction notes

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