Water → [(2R)-1-(2-methylpropyl)pyrrolidin-2-yl]methanamine

Lithium aluminium hydride [1.0 mol soln. in tetrahydrofuran] (11.52 ml, 11.52 mmol) was added to a solution of (2R)-1-isobutyl-2-pyrrolidinecarboxamide (1.3 g, 7.68 mmol) [see preparation 59] in tetrahydrofuran (5 ml) @0° C. The reaction mixture was stirred for 10 mins and then heated to reflux for 6 hrs. Water (0.5 ml) was added to the cooled mixture followed by sodium hydroxide (1.5 ml) and water (1.5 ml). Tetrahydrofuran (10 ml) was added and the mixture was stirred at room temperature for 1 hr. The aluminium salts were removed by filtration and washed well with diethyl ether. The filtrate was then evaporated under reduced pressure to afford the title compound as a white solid, 705 mg, (58%).

1. temperatureheated
2. temperatureto reflux for 6 hrs
3. stirringthe mixture was stirred at room temperature for 1 hr
4. customThe aluminium salts were removed by filtration
5. washwashed well with diethyl ether
6. customThe filtrate was then evaporated under reduced pressure

ORD record

ord-bc5618d8227d4bac880f7935324cad2e

Source dataset

uspto-grants-2002_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06417203B1