Cyclopropylmethyl-2-piperidinecarboxamide → Ammonia

HRID 2228761Notes

Reaction equation

HRID 2228761 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][CH2:8][CH2:7][CH:6]2[C:11]([NH2:13])=O)[CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][CH2:8][CH2:7][C@@H:6]2[CH2:11][NH2:13])[CH2:2][CH2:3]1.[NH3:5]

Participants

4

Reactant 2

HCID 18470902Cyclopropylmethyl-2-piperidinecarboxamideHCID 21226445Aluminium lithium hydride

Product 2

HCID 222AmmoniaHCID 59900487[(2R)-1-(Cyclopropylmethyl)piperidinyl]methylamine

Procedure

The title compound was prepared by a similar method to preparation 60 from (2R-1-(cyclopropylmethyl-2-piperidinecarboxamide [see preparation 69] and lithium aluminium hydride. The crude product was purified by column chromatography on silica gel using dichloromethane:methanol:0.88 ammonia (90:10:0.1) as the eluant, to afford the product as a yellow oil, (71%).

Workup

  1. customThe crude product was purified by column chromatography on silica gel

Sources & evidence

ORD record
ord-2e0f8b0ab1fe431e92e26b7e1f302e76
Source dataset
uspto-grants-2002_07
Patent number
US06417203B1

Reaction notes

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