HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylmethyl-2-piperidinecarboxamide → Ammonia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylmethyl-2-piperidinecarboxamide | HCID 18470902 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Product | Ammonia | HCID 222 | — |
| Product | [(2R)-1-(Cyclopropylmethyl)piperidinyl]methylamine | HCID 59900487 | — |
Reaction Steps
The title compound was prepared by a similar method to preparation 60 from (2R-1-(cyclopropylmethyl-2-piperidinecarboxamide [see preparation 69] and lithium aluminium hydride. The crude product was purified by column chromatography on silica gel using dichloromethane:methanol:0.88 ammonia (90:10:0.1) as the eluant, to afford the product as a yellow oil, (71%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06417203B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-2e0f8b0ab1fe431e92e26b7e1f302e76 |
| Source note | uspto-grants-2002_07 |