Hydrochloric Acid → HCID 12083250, compound

HRID 2229064Notes

Reaction equation

HRID 2229064 reaction equation
C([O:3][C:4](=[O:36])[C:5]([CH3:35])([O:7][C:8]1[CH:13]=[CH:12][C:11]([S:14][CH2:15][CH2:16][C:17]2[N:18]=[C:19]([C:23]3[CH:28]=[CH:27][C:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[CH:25][CH:24]=3)[O:20][C:21]=2[CH3:22])=[CH:10][CH:9]=1)[CH3:6])C.[OH-].[Na+].Cl>CCO>[C:26]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:25]=[CH:24][C:23]([C:19]2[O:20][C:21]([CH3:22])=[C:17]([CH2:16][CH2:15][S:14][C:11]3[CH:12]=[CH:13][C:8]([O:7][C:5]([CH3:35])([CH3:6])[C:4]([OH:36])=[O:3])=[CH:9][CH:10]=3)[N:18]=2)=[CH:28][CH:27]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12083249HCID 12083249, compound

Product 1

HCID 12083250HCID 12083250, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Methyl-2-{4-[2-(5-methyl-2-biphenyl-4-yl-oxazol-4-yl)ethylsulfanyl]phenoxy}propionic acid ethyl ester (0.23 mmol) was dissolved in EtOH (10 mL) and 5N NaOH (0.5 mL) was added. The reaction was stirred overnight at room temperature. The reaction was acidified with 5N HCl and the product was extracted into ethyl acetate, dried (MgSO4) and concentrated to give 96 mg crude product.

Workup

  1. extractionthe product was extracted into ethyl acetate
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-3b91fa993d10456a8ea327dd686508cb
Source dataset
uspto-grants-2002_07
Patent number
US06417212B1

Reaction notes

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