Water → N-(4-(Aminosulphonyl)phenyl)acrylamide
Reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:12](Cl)(=[O:15])[CH:13]=[CH2:14].O>O1CCCC1>[NH2:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:12](=[O:15])[CH:13]=[CH2:14])=[CH:3][CH:4]=1)(=[O:9])=[O:10]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
In 100 mL of tetrahydrofuran was dissolved 17 g of p-aminobenzenesulfonamide. This solution was cooled to 0° C. on an ice bath. To this solution was dropwise added 5 g of acryloyl chloride. After completion of the addition, the ice bath was removed and the reaction mixture was warmed to room temperature and stirred for 1 hour. Subsequently, the reaction mixture was heated at 60° C. for 1 hour. After completion of the reaction, the reaction mixture was poured into 1 L of distilled water. Thus, N-(p-aminosulfonylphenyl)acrylamide was obtained as precipitated white particles.
Workup
- additionAfter completion of the addition
- customthe ice bath was removed
- temperaturethe reaction mixture was warmed to room temperature
- temperatureSubsequently, the reaction mixture was heated at 60° C. for 1 hour
- customAfter completion of the reaction
Sources & evidence
- ORD record
- ord-67cffc79fe1441e8b245d94d876f9fdf
- Source dataset
- uspto-grants-2002_07
- Patent number
- US06420082B1
Reaction notes
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