HCID 131723401, compound → HCID 88184092, compound

HRID 2229122Notes

Reaction equation

HRID 2229122 reaction equation
[Cl:1][C:2]1[CH:17]=[C:16]([F:18])[C:15]([C:19]2[C:24]([F:25])=[CH:23][C:22]([C:26]([F:29])([F:28])[F:27])=[CH:21][N:20]=2)=[CH:14][C:3]=1[O:4][C@H:5]([CH3:13])[C:6]([O:8]CC(C)C)=[O:7]>C(O)(=O)C.Cl>[Cl:1][C:2]1[CH:17]=[C:16]([F:18])[C:15]([C:19]2[C:24]([F:25])=[CH:23][C:22]([C:26]([F:29])([F:27])[F:28])=[CH:21][N:20]=2)=[CH:14][C:3]=1[O:4][C@H:5]([CH3:13])[C:6]([OH:8])=[O:7]

Participants

4

Reactant 1

HCID 131723401HCID 131723401, compound

Product 1

HCID 88184092HCID 88184092, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

2.0 g (0.0046 mol) of the compound of Example 9 were stirred at 80° C. in a mixture of 35 ml of glacial acetic acid and 15 ml of 2 N hydrochloric acid for 3 h. After cooling, the mixture was partitioned between methylene chloride and water and the organic phase was dried and concentrated. 1.6 g (91.7% of theory) of the title compound of mp. 48-50° C. were obtained.

Workup

  1. temperatureAfter cooling
  2. customthe mixture was partitioned between methylene chloride and water
  3. customthe organic phase was dried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-3684ebaf25c04824986e9bedbf70f6e5
Source dataset
uspto-grants-2002_07
Patent number
US06420314B1

Reaction notes

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