Hydrazine hydrate (1:1) → HCID 18466950, compound

HRID 2229159Notes

Reaction equation

HRID 2229159 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[NH:12][CH:11]=[C:10](SC)[O:9]1.O.[NH2:16][NH2:17]>COC(O)C>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[NH:12][CH:11]=[C:10]([NH:16][NH2:17])[O:9]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18466946HCID 18466946, compound

Product 1

HCID 18466950HCID 18466950, compoundYield 36.9%

Reagents, catalysts & solvents 1

HCID 30156371-MethoxyethanolSolvent

Conditions

Temperature
120 °C

Procedure

To a solution of 2-(2-aminophenyl)-5-(methylthio)oxadiazole (1.8 g) in methoxyethanol was added 4.4 g of hydrazine hydrate and the mixture was stirred for 30 h at 120° C. The solvent and excess hydrazine were removed and the residue was purified by column chromatography on silica gel to give 613 mg of 2-(2-aminophenyl)-5-hydrazinooxadiazole.

Workup

  1. customThe solvent and excess hydrazine were removed
  2. customthe residue was purified by column chromatography on silica gel

Sources & evidence

ORD record
ord-39bf63fbebb9467da9336013482c9316
Source dataset
uspto-grants-2002_07
Patent number
US06420367B1

Reaction notes

Loading…