Potassium Carbonate → Ethyl imidazo[1,2-a]pyridine-2-carboxylate

Participants

Reaction Steps

A solution of 7.8 g (40 mmol) of ethyl bromopyruvate and in 40 mL of ethanol is treated with 3.76 g (30.0 mmol) of 2-aminopyrazine and heated to reflux temperature for 16 hr. The reaction mixture is cooled to room temperature and treated with 10 g of potassium carbonate. The mixture is filtered through Celite and the solvent removed in vacuo to yield the crude material. The resulting residue is flash chromatographed with initially 1% methanol in dichloromethane to afford 3.5 g (46%) ethyl imidazolo[1,2-a]pyridine-2-carboxylate.

Provenance & Evidence