Sodium borohydride → HCID 18467036, compound

HRID 2229231Notes

Reaction equation

HRID 2229231 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([CH2:13][CH2:14][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)=[O:12].[BH4-].[Na+]>CO>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]([OH:12])[CH2:13][CH2:14][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 69945910HCID 69945910, compound

Product 1

HCID 18467036HCID 18467036, compoundYield 72.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (2-naphthyl) [2-(3-pyridyl)ethyl]ketone (2.14 g) in MeOH (40 ml) was added NaBH4 (0.34 g) and the mixture was stirred at room temperature for 30 minutes. After removal of the solvent, the residue was extracted with ethyl acetate. The extract was washed with water and brine, dried and concentrated to give the titled compound (1.56 g) as colorless prisms.

Workup

  1. customAfter removal of the solvent
  2. extractionthe residue was extracted with ethyl acetate
  3. washThe extract was washed with water and brine
  4. customdried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-9366400d840048a886b56a15c0a19a4d
Source dataset
uspto-grants-2002_07
Patent number
US06420375B1

Reaction notes

Loading…