Sodium borohydride → HCID 18467038, compound

HRID 2229235Notes

Reaction equation

HRID 2229235 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][C:9]([C:11]2[CH:20]=[CH:19][C:18]3[CH2:17][CH2:16][CH2:15][CH2:14][C:13]=3[CH:12]=2)=[O:10])[CH:2]=1.[BH4-].[Na+]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH:9]([C:11]2[CH:20]=[CH:19][C:18]3[CH2:17][CH2:16][CH2:15][CH2:14][C:13]=3[CH:12]=2)[OH:10])[CH:2]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18467031HCID 18467031, compound

Product 1

HCID 18467038HCID 18467038, compoundYield 51.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of [2-(3-pyridyl)ethyl]-(5,6,7,8-tetrahydronaphthalen-2-yl)ketone (3.02 g) in MeOH (50 ml) was added NaBH4 (0.45 g) and the mixture was stirred at room temperature for 30 minutes. After removal of the solvent, the residue was extracted with ethyl acetate. The extract was washed with water and brine, dried and concentrated to give the titled compound (1.56 g) as an oil.

Workup

  1. customAfter removal of the solvent
  2. extractionthe residue was extracted with ethyl acetate
  3. washThe extract was washed with water and brine
  4. customdried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-0372cfcb9a204a4b8026983318af1fb0
Source dataset
uspto-grants-2002_07
Patent number
US06420375B1

Reaction notes

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