Ethyl 1-benzofuran-2-carboxylate → 1-Benzofuran-2-Ylmethanol

HRID 2229256Notes

Reaction equation

C([O:3][C:4]([C:6]1[O:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[CH:10]=1)=O)C.[H-].C([Al+]CC(C)C)C(C)C>>[OH:3][CH2:4][C:6]1[O:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[CH:10]=1

Participants

Reactant 2

HCID 641368Ethyl 1-benzofuran-2-carboxylate

HCID 21225700Diisobutylaluminumhydride

Product 1

HCID 27762631-Benzofuran-2-YlmethanolYield 79.2%

Procedure

The reaction of 2-ethoxycarbonylbenzofurane (27.40 g) with diisobutylaluminum hydride was carried out in the manner similar to that described in Reference Example 3 to give the titled compound (16.91 g) as a colorless oil. This compound was used without further purification.

Sources & evidence

ORD record: ord-edbf7a3e9d6e4484b4dd46671d59b14c
Source dataset: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06420375B1

Reaction notes

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