Acetyl chloride → 1-(5-Fluoro-3-methyl-1-benzothiophen-2-yl)ethan-1-one

HRID 2229260Notes

Reaction equation

[F:1][C:2]1[CH:11]=[CH:10][C:5]2[S:6][CH:7]=[C:8]([CH3:9])[C:4]=2[CH:3]=1.[C:12](Cl)(=[O:14])[CH3:13]>>[C:12]([C:7]1[S:6][C:5]2[CH:10]=[CH:11][C:2]([F:1])=[CH:3][C:4]=2[C:8]=1[CH3:9])(=[O:14])[CH3:13]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 5968285-Fluoro-3-methyl-benzo[b]thiophene

Product 1

HCID 184669981-(5-Fluoro-3-methyl-1-benzothiophen-2-yl)ethan-1-one

Procedure

The titled compound (7.43 g) was prepared as colorless crystals from 5-fluoro-3-methylbenzo[b]thiophene (9.97 g) and acetyl chloride (5.55 ml) by the similar reaction and purification procedure as described in Reference Example 35.

Sources & evidence

ORD record: ord-65998432506a42aba9a2dc5ae4cc508c
Source dataset: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06420375B1

Reaction notes

Loading…