Water → 2-Ethylamino-3-nitropyridine

HRID 2229300Notes

Reaction equation

HRID 2229300 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12].O>C1COCC1>[CH2:11]([NH:13][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1)[CH3:12]

Participants

5

Reactant 3

HCID 962WaterHCID 6341EthylamineHCID 796132-Chloro-3-nitropyridine

Product 1

HCID 120157272-Ethylamino-3-nitropyridine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of 2-chloro-3-nitropyridine (51 g, 325 mmol) in THF (650 mL) was added a 2 M solution of ethylamine in THF (365 mL, 731 mmol). The reaction was stirred at room temperature overnight. The reaction mixture was poured into water (˜1.5 L) and the resulting solid was filtered and dried under reduced pressure to give the title compound (52 g).

Workup

  1. filtrationthe resulting solid was filtered
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-6dbf7c26a3a34e8b80800167216e79d0
Source dataset
uspto-grants-2002_07
Patent number
US06420359B1

Reaction notes

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