HCID 18466607, compound → HCID 18466603, compound

HRID 2229346Notes

Reaction equation

HRID 2229346 reaction equation
[CH2:1]([NH:3][C:4]1[C:9]([N+:10]([O-])=O)=[CH:8][CH:7]=[C:6]([C:13]([F:16])([F:15])[F:14])[N:5]=1)[CH3:2]>CO.[OH-].[OH-].[Pd+2]>[NH2:10][C:9]1[C:4]([NH:3][CH2:1][CH3:2])=[N:5][C:6]([C:13]([F:14])([F:15])[F:16])=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 18466607HCID 18466607, compound

Product 1

HCID 18466603HCID 18466603, compoundYield 99.5%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

A solution of 2-(ethylamino)-3-nitro-6-(trifluoromethyl)pyridine (1.1 g, 4.9 mmol) in MeOH (40 mL) was stirred overnight at room temperature under hydrogen (1 atm.) in the presence of 20% Pd(OH)2/C (100 mg). The catalyst was removed by filtration through diatomaceous earth. The filtrate was concentrated under reduced pressure to give the title compound as an orange oil (1 g).

Workup

  1. customThe catalyst was removed by filtration through diatomaceous earth
  2. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d342be6adbd74fe3bcec0faf7549de82
Source dataset
uspto-grants-2002_07
Patent number
US06420359B1

Reaction notes

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