HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → Morpholine-4-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 4-Morpholinecarbonyl chloride | HCID 84810 | — |
| Reactant | HCID 22260424 | HCID 22260424 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Morpholine-4-carboxylic Acid | HCID 9833960 | — |
Reaction Steps
The title compound is prepared from morpholine-4-carboxylic acid [1-(4-cyano-piperidin-4-ylcarbamoyl)-3,3-dimethyl-butyl]-amide hydrochloride and 4-morpholine carbonyl chloride in the presence of a tertiary amine base such as N-methylmorpholine in a solvent such as methylene chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06420364B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-f81866f2a003480899fbf8ee3c0bf425 |
| Source note | uspto-grants-2002_07 |