4-Methylmorpholine → Morpholine-4-carboxylic Acid

HRID 2229368Notes

Reaction equation

HRID 2229368 reaction equation
Cl.C(C1(NC(C(N[C:20]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[O:21])CC(C)(C)C)=O)CCNCC1)#N.N1(C(Cl)=O)CC[O:31]CC1.CN1CCOCC1>C(Cl)Cl>[N:22]1([C:20]([OH:21])=[O:31])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1

Participants

5

Reactant 3

HCID 79724-MethylmorpholineHCID 848104-Morpholinecarbonyl chlorideHCID 22260424HCID 22260424, compound

Product 1

HCID 9833960Morpholine-4-carboxylic Acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound is prepared from morpholine-4-carboxylic acid [1-(4-cyano-piperidin-4-ylcarbamoyl)-3,3-dimethyl-butyl]-amide hydrochloride and 4-morpholine carbonyl chloride in the presence of a tertiary amine base such as N-methylmorpholine in a solvent such as methylene chloride.

Sources & evidence

ORD record
ord-f81866f2a003480899fbf8ee3c0bf425
Source dataset
uspto-grants-2002_07
Patent number
US06420364B1

Reaction notes

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