反应详情

温度

67.5 °C

Eprosartan anhydrate was suspended in an aqueous solution of 3.0 M methanesulfonic acid. The suspension was continuously stirred and heated to 65-70° C. The filtrate obtained by suction was maintained at 75° C. for several minutes to ensure the absence of the anhydrate in solution. The solution was slowly cooled to ambient temperature and clear colorless crystalline drug substance was harvested by filtration and air dried.

1. customThe filtrate obtained by suction
2. temperaturewas maintained at 75° C. for several minutes
3. temperatureThe solution was slowly cooled to ambient temperature
4. filtrationclear colorless crystalline drug substance was harvested by filtration and air
5. customdried