Methanesulfonic Acid → 197855-71-3

HRID 2229421Notes

Reaction equation

HRID 2229421 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[N:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]([OH:19])=[O:18])=[CH:15][CH:16]=2)[C:8](/[CH:20]=[C:21](/[C:28]([OH:30])=[O:29])\[CH2:22][C:23]2[S:27][CH:26]=[CH:25][CH:24]=2)=[CH:7][N:6]=1.[CH3:31][S:32]([OH:35])(=[O:34])=[O:33]>>[OH2:18].[OH2:33].[CH3:31][S:32]([OH:35])(=[O:34])=[O:33].[CH2:4]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([OH:19])=[O:18])=[CH:13][CH:12]=2)[C:8](/[CH:20]=[C:21](\[CH2:22][C:23]2[S:27][CH:26]=[CH:25][CH:24]=2)/[C:28]([OH:30])=[O:29])=[CH:7][N:6]=1)[CH2:3][CH2:2][CH3:1]

Participants

3

Reactant 2

HCID 6395Methanesulfonic AcidHCID 5281037Eprosartan

Product 1

HCID 9872439197855-71-3

Conditions

Temperature
67.5 °C

Procedure

Eprosartan anhydrate was suspended in an aqueous solution of 3.0 M methanesulfonic acid. The suspension was continuously stirred and heated to 65-70° C. The filtrate obtained by suction was maintained at 75° C. for several minutes to ensure the absence of the anhydrate in solution. The solution was slowly cooled to ambient temperature and clear colorless crystalline drug substance was harvested by filtration and air dried.

Workup

  1. customThe filtrate obtained by suction
  2. temperaturewas maintained at 75° C. for several minutes
  3. temperatureThe solution was slowly cooled to ambient temperature
  4. filtrationclear colorless crystalline drug substance was harvested by filtration and air
  5. customdried

Sources & evidence

ORD record
ord-ffb85ad34c374ee8ace64689f05dbd4e
Source dataset
uspto-grants-2002_07
Patent number
US06420412B2

Reaction notes

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