Potassium Hydroxide → HCID 70179137, compound

HRID 2229424Notes

Reaction equation

HRID 2229424 reaction equation
[O:1]=[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([CH2:11][C:12]([O:14]CC)=[O:13])[C:4]=2[N:3]1[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[OH-].[K+]>C(O)C>[O:1]=[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([CH2:11][C:12]([OH:14])=[O:13])[C:4]=2[N:3]1[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 70178073HCID 70178073, compound

Product 1

HCID 70179137HCID 70179137, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-(2-oxo-3-benzylbenzimidazolyl)acetate (4.19 mmol, 1.3 g) (example 1) is added to potassium hydroxide (13.41 mmol, 0.75 g) in ethanol (10 ml), and the mixture is stirred at reflux for 2 hours. The solvent is evaporated and water (40 ml) is added. The pH is adjusted to 1-2 with concentrated hydrochloric acid. The colorless precipitate is filtered off and dried in vacuo to yield the title compound (87%) (R1=CH2—C(O)—OH, R2=benzyl, n=0).

Workup

  1. temperatureat reflux for 2 hours
  2. customThe solvent is evaporated
  3. additionwater (40 ml) is added
  4. filtrationThe colorless precipitate is filtered off
  5. customdried in vacuo

Sources & evidence

ORD record
ord-b14130cafb1a4c78b96a1bf5a8f4ebfd
Source dataset
uspto-grants-2002_07
Patent number
US06420410B1

Reaction notes

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