Potassium Hydroxide → HCID 70179137, compound

Participants

Reaction Steps

Ethyl 2-(2-oxo-3-benzylbenzimidazolyl)acetate (4.19 mmol, 1.3 g) (example 1) is added to potassium hydroxide (13.41 mmol, 0.75 g) in ethanol (10 ml), and the mixture is stirred at reflux for 2 hours. The solvent is evaporated and water (40 ml) is added. The pH is adjusted to 1-2 with concentrated hydrochloric acid. The colorless precipitate is filtered off and dried in vacuo to yield the title compound (87%) (R1=CH2—C(O)—OH, R2=benzyl, n=0).

Provenance & Evidence