Hydrochloric Acid → HCID 22508759, compound

HRID 2229468Notes

Reaction equation

HRID 2229468 reaction equation
[OH-].[Na+].C(O)C.[CH2:6]([O:10][C:11]1[CH:32]=[CH:31][C:14]([CH2:15][N:16]2[C:20]3[CH:21]=[CH:22][CH:23]=[C:24]([C:25]([O:27]CC)=[O:26])[C:19]=3[N:18]=[C:17]2[CH3:30])=[C:13]([Cl:33])[CH:12]=1)[CH2:7][CH2:8][CH3:9].Cl>O>[CH2:6]([O:10][C:11]1[CH:32]=[CH:31][C:14]([CH2:15][N:16]2[C:20]3[CH:19]=[C:24]([C:25]([OH:27])=[O:26])[CH:23]=[CH:22][C:21]=3[N:18]=[C:17]2[CH3:30])=[C:13]([Cl:33])[CH:12]=1)[CH2:7][CH2:8][CH3:9]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 18467625HCID 18467625, compound

Product 1

HCID 22508759HCID 22508759, compoundYield 72.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium hydroxide (0.17 g), ethanol (8 ml), and water (4 ml) were added to 1-(4-butyloxy2-chlorobenzyl)(ethoxycarbonyl)-2-methylbenzimidazole (0.62 g) and the whole was s d for 4 hours at 80° C. The pH was adjusted to about 5 with 35% hydrochloric acid. Deposited crystals were filtered and dried to obtain crystals (0.42 g) of 1-(4-butyloxy-2-chlorobenzyl)-6-carboxy-2-methyl-benzimidazole. [Physicochemical properties of the compound]

Workup

  1. filtrationDeposited crystals were filtered
  2. customdried

Sources & evidence

ORD record
ord-17d89dcb445040cab79e297057515afe
Source dataset
uspto-grants-2002_07
Patent number
US06420409B1

Reaction notes

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