HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → Boc-hyp-obzl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | benzyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate | HCID 6993393 | — |
| Reactant | Tert-butyldicarbonate | HCID 22064466 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Boc-hyp-obzl | HCID 11902907 | 73.9% |
Reaction Steps
t-Butyldicarbonate (1.1 g) and then sat. sodium bicarbonate (20 ml) were added to a suspension of trans-Hyp-OBn (1.1 g) in THF (25 ml) and the mixture stirred for 30 min. The mixture was diluted with ethyl acetate and washed with water, dried (MgSO4) and evaporated. Flash chromatography (SiO2 DCM then ether) gave Boc-Hyp-OBn 1.18 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06420438B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-3d9ece7082324029926ba4c5a934059a |
| Source note | uspto-grants-2002_07 |