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HRID2229589

反应详情

EQUATION

反应方程式

HRID 2229589 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

结构：O=C(OCc1ccccc1)[C@@H]1C[C@@H](O)CN1
HCID6993393

未命名化合物

结构：CC(C)(C)OC(=O)OC(=O)[O-]
HCID22064466

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)OCc1ccccc1
HCID11902907

未命名化合物

收率 73.9%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

t-Butyldicarbonate (1.1 g) and then sat. sodium bicarbonate (20 ml) were added to a suspension of trans-Hyp-OBn (1.1 g) in THF (25 ml) and the mixture stirred for 30 min. The mixture was diluted with ethyl acetate and washed with water, dried (MgSO4) and evaporated. Flash chromatography (SiO2 DCM then ether) gave Boc-Hyp-OBn 1.18 g.

WORKUP

后处理

  1. washwashed with water
  2. dry with materialdried (MgSO4)
  3. customevaporated