Phosphorus oxychloride → 2-Chloro-3-methyl-6-pyridin-4-yl-5-m-tolyl-3H-pyrimidin-4-one

HRID 2229783Notes

Reaction equation

HRID 2229783 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)=[C:5]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[NH:4][C:3]1=O.P(Cl)(Cl)([Cl:25])=O>>[Cl:25][C:3]1[N:2]([CH3:1])[C:7](=[O:8])[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)=[C:5]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[N:4]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 223465713-methyl-5-(3-methylphenyl)-6-(4-pyridyl)-2,4(1H,3H)-pyrimidindione

Product 1

HCID 161156882-Chloro-3-methyl-6-pyridin-4-yl-5-m-tolyl-3H-pyrimidin-4-one

Procedure

A mixture of 3-methyl-5-(3-methylphenyl)-6-(4-pyridyl)-2,4(1H,3H)-pyrimidindione (12.5 g, 0.043 mol) and phosphorus oxychloride (65 ml) was refluxed for 16 h. The excess of phosphorus oxychloride was evaporated followed by co-distillation with toluene. The remainder was carefully partitioned between dichloromethane and aqueous sodium hydrogencarbonate. The organic solution was washed with water, dried and evaporated to leave the title compound. MS (m/z): 312 (M)+; C17H14ClN3O requir. 311.8.

Workup

  1. temperaturewas refluxed for 16 h
  2. customThe excess of phosphorus oxychloride was evaporated
  3. customThe remainder was carefully partitioned between dichloromethane and aqueous sodium hydrogencarbonate
  4. washThe organic solution was washed with water
  5. customdried
  6. customevaporated

Sources & evidence

ORD record
ord-69ae4def873449bc9defc6d7da8d0d6f
Source dataset
uspto-grants-2002_07
Patent number
US06420385B1

Reaction notes

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