Potassium Bromide → HCID 54463444, compound

HRID 2229937Notes

Reaction equation

C([C:8]1[N:13]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[C:12](=[O:19])[C:11]([NH:20][C:21]([O:23][CH2:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28]C=2)=[O:22])=[CH:10][CH:9]=1)C1C=CC=CC=1.[K+].[Br-]>>[CH2:24]([O:23][C:21]([NH:20][C:11]1[C:12](=[O:19])[N:13]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[CH:8]=[CH:9][CH:10]=1)=[O:22])[C:25]1[CH:26]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

Reactant 2

HCID 253877Potassium Bromide

HCID 22104289HCID 22104289, compound

Product 1

HCID 54463444HCID 54463444, compound

Procedure

Methyl [6-benzyl-1,2-dihydro-2-oxo-3-(2-phenylethoxy)carbonylamino-1-pyridyl]acetate (49i), was isolated (88%) as a colorless solid: mp. 130-133° C.; IR (KBr) 3363, 1746, 1732, 1651, 1604, 1515, 1368, 1231, 1212, 1185; 1H NMR (CDCl3) δ8.00 (1H, d, J=7.0), 7.68 (1H, s), 7.36-7.10 (10H, m), 6.15 (1H, d, J=7.6), 4.7 (2H, s), 4.38 (2H, t, J=7.0), 3.88 (2H, s), 3.67 (3H, s), 2.98 (2H, t, J=7).

Sources & evidence

ORD record: ord-127f5d0b56a04af5b94d893415d452f2
Source dataset: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06420522B1

Reaction notes

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