Hydrazine hydrate (1:1) → HCID 131722383, compound

HRID 2229996Notes

Reaction equation

HRID 2229996 reaction equation
S(C1C=CC(C)=CC=1)(O)(=O)=O.S(C1C=CC(C)=CC=1)(O)(=O)=O.C1(=O)[N:27]([C:28]([N:45]2C(=O)C3=CC=CC=C3C2=O)([CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[O:29][O:30][O:31][O:32][OH:33])C(=O)C2=CC=CC=C12.O.NN>C(O)C>[NH2:45][C:28]([NH2:27])([CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[O:29][O:30][O:31][O:32][OH:33]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 131722381HCID 131722381, compound

Product 1

HCID 131722383HCID 131722383, compoundYield 173.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of diphthalimide (Step 4, 60 g), hydrazine hydrate (15 g) and ethanol (500 mL) is heated at 100° C. with stirring for 3 hours. The reaction mixture is cooled to room temperature and filtered. The solid is washed with cold ethanol. The combined filtrate is combined and concentrated under vacuum in a rotary evaporator to afford 33 g of yellow oil.

Workup

  1. filtrationfiltered
  2. washThe solid is washed with cold ethanol
  3. concentrationconcentrated under vacuum in a rotary evaporator

Sources & evidence

ORD record
ord-73b58f4ba9e849138b6b18572dde1b0e
Source dataset
uspto-grants-2002_07
Patent number
US06423497B1

Reaction notes

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