Lithium → HCID 70126812, compound

HRID 2230006Notes

Reaction equation

HRID 2230006 reaction equation
[Li:1].C1([P:8]2[C:12]([CH3:13])=[C:11]([CH3:14])[C:10]([CH3:15])=[C:9]2[CH3:16])C=CC=CC=1>O1CCCC1>[Li:1].[CH3:16][C:9]1[PH:8][C:12]([CH3:13])=[C:11]([CH3:14])[C:10]=1[CH3:15]

Participants

4

Reactant 2

HCID 3028194LithiumHCID 14026308HCID 14026308, compound2×

Product 1

HCID 70126812HCID 70126812, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
0 °C

Procedure

Corresponding to the procedure described in Organometallics 7 (1988), 921, 0.52 g (0.074 mole) lithium was added to a solution of 7 g (0.032 mole) of compound 7 in 150 ml tetrahydrofuran (THF) and was stirred overnight. The red solution obtained was filtered through a frit to remove residual solids and the filtrate was cooled to 0° C. Thereafter, a solution of 1.45 g (0.01 mole) AlCl in 20 ml THF was added drop-wise and the solution was brought to room temperature. An aliquot portion was taken for analysis and the remaining solution was used directly for the preparation of compound 9.

Workup

  1. customThe red solution obtained
  2. filtrationwas filtered through a frit
  3. customto remove residual solids
  4. customwas brought to room temperature

Sources & evidence

ORD record
ord-2cddb1d4d3b34662a39ce8a3bbb6d5ef
Source dataset
uspto-grants-2002_07
Patent number
US06423659B1

Reaction notes

Loading…