Dichloromethane → HCID 11258008, compound

HRID 2230096Notes

Reaction equation

HRID 2230096 reaction equation
C(Cl)Cl.[C:4]([O:8][C:9]([N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)=[O:10])([CH3:7])([CH3:6])[CH3:5].[O:17]([C:24]1[CH:29]=[CH:28][C:27]([N:30]=[C:31]=[O:32])=[CH:26][CH:25]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CO>[C:4]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:31](=[O:32])[NH:30][C:27]2[CH:26]=[CH:25][C:24]([O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:29][CH:28]=2)[CH2:13][CH2:12]1)=[O:10])([CH3:7])([CH3:5])[CH3:6]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 143452tert-Butyl piperazine-1-carboxylateHCID 27348964-Phenoxyphenyl isocyanate

Product 1

HCID 11258008HCID 11258008, compoundYield 107.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a methylene chloride solution (25 mL) of N-tert-butoxycarbonylpiperazine (2.50 g, 13.4 mmol), 4-phenoxyphenyl isocyanate (2.83 mL, 13.4 mmol) was added, followed by stirring at room temperature overnight. Methanol was added to the reaction solution, and the solvent was evaporated to give the target compound (5.71 g, 14.4 mmol).

Workup

  1. customthe solvent was evaporated

Sources & evidence

ORD record
ord-d93d0a7e68354cbc98114b0bac1911ad
Source dataset
uspto-grants-2002_07
Patent number
US06423716B1

Reaction notes

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