2-Naphthalenesulfonyl chloride → Naphthalene-2-sulfonic Acid [4-Bromo-3-(4-methylpiperazin-1-yl)phenyl]amide

HRID 2230129Notes

Reaction equation

HRID 2230129 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11][CH2:10]1.[CH:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][C:17]=1[S:26](Cl)(=[O:28])=[O:27]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:26]([C:17]2[CH:18]=[CH:19][C:20]3[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:16]=2)(=[O:28])=[O:27])=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:11][N:12]([CH3:15])[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 181800994-Bromo-3-(4-methylpiperazin-1-yl)aniline

Product 1

HCID 18180049Naphthalene-2-sulfonic Acid [4-Bromo-3-(4-methylpiperazin-1-yl)phenyl]amide

Procedure

The title compound (E120) was prepared from 4-bromo-3-(4-methylpiperazin-1-yl)benzenamine (EP 0533267A, intermediate 61) (600 mg, 2.23 mmol) and naphthalene-2-sulfonyl chloride (504 mg, 2.23 mmol) using the method of Example 1 (939 mg, 92%) MH+=460/462.

Sources & evidence

ORD record
ord-f5dbd87e2b0343799f8af63bc0af0c59
Source dataset
uspto-grants-2002_07
Patent number
US06423717B1

Reaction notes

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