5-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chloride → HCID 18180122, compound

HRID 2230130Notes

Reaction equation

HRID 2230130 reaction equation
[CH3:1][N:2]([CH3:14])[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:10]=[CH:11][C:12]=1[I:13])[NH2:9].[Cl:15][C:16]1[CH:29]=[CH:28][C:19]2[S:20][C:21]([S:24](Cl)(=[O:26])=[O:25])=[C:22]([CH3:23])[C:18]=2[CH:17]=1>>[CH3:1][N:2]([CH3:14])[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([NH:9][S:24]([C:21]2[S:20][C:19]3[CH:28]=[CH:29][C:16]([Cl:15])=[CH:17][C:18]=3[C:22]=2[CH3:23])(=[O:26])=[O:25])[CH:10]=[CH:11][C:12]=1[I:13]

Participants

3

Reactant 2

HCID 27357565-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chlorideHCID 10881314HCID 10881314, compound

Product 1

HCID 18180122HCID 18180122, compound

Procedure

The title compound was prepared from 3-(2-dimethylaminoethoxy)-4iodoaniline (WO95/15954, Description 50) (109 mg, 0.36 mmol) and 5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride (100 mg, 0.36 mmol) using the method of Example 1 (70 mg, 36%) MH+=551/553.

Sources & evidence

ORD record
ord-df6058ef2bc244a0a83e431bb53279cb
Source dataset
uspto-grants-2002_07
Patent number
US06423717B1

Reaction notes

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