5-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chloride → HCID 18180163, compound

HRID 2230133Notes

Reaction equation

HRID 2230133 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[C:5]([CH3:10])[C:4]=1[N:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[Cl:18][C:19]1[CH:32]=[CH:31][C:22]2[S:23][C:24]([S:27](Cl)(=[O:29])=[O:28])=[C:25]([CH3:26])[C:21]=2[CH:20]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][S:27]([C:24]2[S:23][C:22]3[CH:31]=[CH:32][C:19]([Cl:18])=[CH:20][C:21]=3[C:25]=2[CH3:26])(=[O:29])=[O:28])=[C:5]([CH3:10])[C:4]=1[N:11]1[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 27357565-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chlorideHCID 18180069HCID 18180069, compound

Product 1

HCID 18180163HCID 18180163, compound

Procedure

The title compound (E125) was prepared from 4-methoxy-2-methyl-3-(4-methylpiperazin-1-yl)phenylamine (D33) (58 mg, 0.247 mmol) and 5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride (70 mg, 0.247 mmol) using the method of Example 1 (103 mg, 81%). MH+=480/482.

Sources & evidence

ORD record
ord-460181f2db5f4ad6a8d61d72ff8c24b4
Source dataset
uspto-grants-2002_07
Patent number
US06423717B1

Reaction notes

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