p-Bromobenzenesulfonyl chloride → HCID 18180189, compound

HRID 2230136Notes

Reaction equation

HRID 2230136 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][C:4]=1[C:10]1[CH2:11][CH2:12][N:13]([CH3:16])[CH2:14][CH:15]=1.[Br:17][C:18]1[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1>>[Br:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([NH:9][C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[C:4]([C:10]3[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH:11]=3)[CH:5]=2)(=[O:26])=[O:25])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 18180121HCID 18180121, compound

Product 1

HCID 18180189HCID 18180189, compound

Procedure

The title compound (E129) was prepared from 4-methoxy-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenylamine (free base of D39) (107 mg; 0.49 mmol) and 4-bromobenzenesulfonylchloride (125 mg, 0.49 mmol) using the method of Example 1 (179 mg, 77%) MH+=437/439.

Sources & evidence

ORD record
ord-71f50597f45f4dde8f03cb00e2bd1dc2
Source dataset
uspto-grants-2002_07
Patent number
US06423717B1

Reaction notes

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