Trifluoroacetic acid → HCID 7020604, compound

HRID 2230222Notes

Reaction equation

HRID 2230222 reaction equation
[NH:1]([C:17]([O:19][CH2:20][CH:21]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:27]2[C:22]1=[CH:23][CH:24]=[CH:25][CH:26]=2)=[O:18])[C@H:2]([C:11]([O:13][CH2:14][CH:15]=[CH2:16])=[O:12])[CH2:3][C:4](=[O:10])[O:5]C(C)(C)C.FC(F)(F)C(O)=O>>[NH:1]([C:17]([O:19][CH2:20][CH:21]1[C:22]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:28]2[C:33]1=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:18])[C@H:2]([C:11]([O:13][CH2:14][CH:15]=[CH2:16])=[O:12])[CH2:3][C:4](=[O:5])[OH:10]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11662410HCID 11662410, compound

Product 1

HCID 7020604HCID 7020604, compound

Procedure

FmocAsp(OtBu)Oallyl (40 g, 88.7 mmol) was treated with 25 ml of trifluoroacetic acid and the mixture was stirred at room temperature for 30 min. The solvent was stripped off on a rotary evaporator. The residue was dried in vacuo. FmocAsp(OH)Oallyl was obtained as a yellow oil (33.9 g, 97%). ES(+)-MS: 395.2 (M+H)+

Workup

  1. customThe solvent was stripped off on a rotary evaporator
  2. customThe residue was dried in vacuo

Sources & evidence

ORD record
ord-89f176cab227429d82dbe3868ed3dfee
Source dataset
uspto-grants-2002_07
Patent number
US06423712B1

Reaction notes

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