Sodium Fluoride → Phenyl Fluoroformate

HRID 2230253Notes

Reaction equation

HRID 2230253 reaction equation
[C:1]1([O:7][C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F-:11].[Na+].C1OCCOCCOCCOCCOC1>C(#N)C>[C:1]1([O:7][C:8]([F:11])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 5235Sodium FluorideHCID 15891Phenyl chloroformateHCID 3633615-Crown-52×

Product 1

HCID 11815898Phenyl Fluoroformate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
40 °C

Procedure

To a solution of phenylchloroformate in acetonitrile is charged sodium fluoride. To this mixture is charged the 15-crown-5 (“15C5”)at ambient temperature. The reaction mixture is then heated to 40° C. for approximately 16 hrs. Reaction completion is monitored by gas chromatography (“G.C.”).

Workup

  1. customReaction completion

Sources & evidence

ORD record
ord-dcd9b198eb6e48468c4e1093779a5e63
Source dataset
uspto-grants-2002_07
Patent number
US06423862B1

Reaction notes

Loading…