Sodium Hydroxide → HCID 18466212, compound

HRID 2230260Notes

Reaction equation

HRID 2230260 reaction equation
C([O:3][C:4](=[O:24])[CH:5]([CH2:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][C:13]=1[O:22][CH3:23])[C:6]([O:8]CC)=[O:7])C.[OH-].[Na+]>O>[CH3:23][O:22][C:13]1[CH:14]=[CH:15][C:16]2[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:12]=1[CH2:11][CH:5]([C:6]([OH:8])=[O:7])[C:4]([OH:24])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18466198HCID 18466198, compound

Product 1

HCID 18466212HCID 18466212, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

In a 1 litre single-necked flask, the compound obtained in Step B (20 g, 6.05.10−2 mol) is heated at reflux in the presence of sodium hydroxide (20 g, 5.00.10−1 mol) and water (340 ml) for 4 hours 30 minutes. After cooling, the mixture is diluted with 150 ml of water, filtered through filter paper and acidified using concentrated hydrochloric acid in the hot state (80-90° C.); the white microspheres formed in the hot state are filtered off over a frit after complete cooling. The diacid is washed with cold water. After drying in an oven (110° C.) for one night, the title compound is dried in a desiccator in the presence of P2O5.

Workup

  1. temperatureAfter cooling
  2. filtrationfiltered
  3. filtrationthrough filter paper
  4. customin the hot state (80-90° C.)
  5. customthe white microspheres formed in the hot state
  6. filtrationare filtered off over a frit after complete cooling
  7. washThe diacid is washed with cold water
  8. customAfter drying in an oven (110° C.) for one night
  9. dry with materialthe title compound is dried in a desiccator in the presence of P2O5

Sources & evidence

ORD record
ord-e67a4aba68654ef98f6192a7dbfd1329
Source dataset
uspto-grants-2002_07
Patent number
US06423870B1

Reaction notes

Loading…