反应详情

A solution of the product from Example 1 (0.20 g, 0.35 mmol) in 16 mL of tetrahydrofuran was hydrogenated at 52 psi over 20% Pd/C for 48 hours. The reaction mixture was filtered through Celite using methanol and concentrated. The resulting foam was purified by chromatography (silica gel, 1:1 heptane/ethyl acetate). The product was isolated as a foam and dried under vacuum to give the title compound (0.16 g, 95%).

1. filtrationThe reaction mixture was filtered through Celite
2. concentrationconcentrated
3. customThe resulting foam was purified by chromatography (silica gel, 1:1 heptane/ethyl acetate)
4. customThe product was isolated as a foam
5. customdried under vacuum