HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → diphenylmethyl (S)-3-[(2S,3R,4R,5S)-2,3,4,6-tetrahydroxy-5-(L-leucyl)aminohexanoyl]amino-3-phenylpropionate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | diphenylmethyl (S)-3-[(2S,3R,4R,5S)-2,3,4,6-tetrahydroxy-5-(L-leucyl)aminohexanoyl]amino-3-phenylpropionate | HCID 11039599 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | diphenylmethyl (S)-3-[(2S,3R,4R,5S)-2,3,4,6-tetrahydroxy-5-(L-leucyl)aminohexanoyl]amino-3-phenylpropionate hydrochloride | HCID 86758377 | — |
Reaction Steps
To a solution of diphenylmethyl (S)-3-[(2S,3R,4R,5S)-2,3,4,6-tetrahydroxy-5-(L-leucyl)aminohexanoyl]amino-3-phenylpropionate (246 mg) in methanol (1 ml) was added 1N hydrochloric acid (0.396 ml) at room temperature. Concentration gave a residue, which was recrystallized from methanol-diethylether to afford the title compound (180 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06423869B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-a5f371af95b54eae88955f2c09e6e645 |
| Source note | uspto-grants-2002_07 |