HRID2230400

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CC(C)C[C@H](N)C(=O)N[C@@H](CO)[C@@H](O)[C@@H](O)[C@H](O)C(=O)N[C@@H](CC(=O)OC(c1ccccc1)c1ccccc1)c1ccccc1

HCID11039599

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@H](N)C(=O)N[C@@H](CO)[C@@H](O)[C@@H](O)[C@H](O)C(=O)N[C@@H](CC(=O)OC(c1ccccc1)c1ccccc1)c1ccccc1.Cl

HCID86758377

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of diphenylmethyl (S)-3-[(2S,3R,4R,5S)-2,3,4,6-tetrahydroxy-5-(L-leucyl)aminohexanoyl]amino-3-phenylpropionate (246 mg) in methanol (1 ml) was added 1N hydrochloric acid (0.396 ml) at room temperature. Concentration gave a residue, which was recrystallized from methanol-diethylether to afford the title compound (180 mg).

WORKUP

后处理

concentrationConcentration
customgave a residue, which
customwas recrystallized from methanol-diethylether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a5f371af95b54eae88955f2c09e6e645
来源数据集: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06423869B1
来源说明: uspto-grants-2002_07

反应 SMILES

[OH:1][C@@H:2]([C@H:30]([OH:45])[C@H:31]([OH:44])[C@@H:32]([NH:35][C:36](=[O:43])[C@H:37]([CH2:39][CH:40]([CH3:42])[CH3:41])[NH2:38])[CH2:33][OH:34])[C:3]([NH:5][C@H:6]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:7][C:8]([O:10][CH:11]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])=[O:4].[ClH:46]>CO>[ClH:46].[OH:1][C@@H:2]([C@H:30]([OH:45])[C@H:31]([OH:44])[C@@H:32]([NH:35][C:36](=[O:43])[C@H:37]([CH2:39][CH:40]([CH3:41])[CH3:42])[NH2:38])[CH2:33][OH:34])[C:3]([NH:5][C@H:6]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[CH2:7][C:8]([O:10][CH:11]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9])=[O:4]