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HRID2230442

反应详情

EQUATION

反应方程式

HRID 2230442 的结构方程式

REACTANTS

反应物

3
结构：[Br-].[K+]
HCID253877

Potassium bromide

BrK

结构：O=C(N[C@H]1CCC(=O)N2CCC[C@@H](C(=O)O)N2C1=O)c1ccccc1
HCID18396548

未命名化合物

结构：CC(C)(C)OC(=O)[C@@H]1CCCN2C(=O)CC[C@H](NC(=O)OCC3c4ccccc4-c4ccccc43)C(=O)N12
HCID67022165

未命名化合物

PRODUCTS

生成物

1
结构：O=C(N[C@H]1CCC(=O)N2CCC[C@@H](C(=O)O)N2C1=O)OCC1c2ccccc2-c2ccccc21
HCID18396546

未命名化合物

收率 96%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

was prepared from 211f in 96% yield by the same method as for 212e: mp 120-126° C.; [α]D25 −72.5° (c 0.1, CH2Cl2). IR (KBr) 3406, 2950, 1725, 1670, 1526, 1449, 1421, 1272, 1248, 1223, 1175, 761, 741; 1H NMR (CDCl3) δ7.76 (2H, m), 7.62-7.26 (4H, m), 6.07, 5.76 (2H, brs, d, d, J=2.9), 5.46, 5.36 (1H, 2m), 4.79-4.54 (2H, m), 4.77 (2H, m), 4.21 (1H, m), 3.41 (1H, m), 2.89 (1H, m), 2.69 (1H, m), 2.35 (2H, m), 1.98, 1.73 (4H, 2m). MS (ES−, m/z) 462 (M+−1, 50%), 240 (100%).