Dichloromethane → HCID 66756432, compound

HRID 2230464Notes

Reaction equation

HRID 2230464 reaction equation
[CH3:1][O:2][C:3](=[O:25])[CH2:4][N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[NH:9][CH2:8][C@H:7]([NH:16]C(OC(C)(C)C)=O)[C:6]1=[O:24].C(Cl)[Cl:27]>>[ClH:27].[CH3:1][O:2][C:3](=[O:25])[CH2:4][N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[NH:9][CH2:8][C@H:7]([NH2:16])[C:6]1=[O:24]

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 54305289(3S)-2-Oxo-3-tert-butoxycarbonylamino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester

Product 1

HCID 66756432HCID 66756432, compound

Procedure

(600a/103, 4.0 g, 11.4 mmol) in 20 ml of CH2Cl2 for 20 min then stirred for 1 h at RT. The reaction was evaporated to give (3S)-2-oxo-3-amino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester hydrochloride as a white solid.

Workup

  1. customThe reaction was evaporated

Sources & evidence

ORD record
ord-443f277eef3e446ebc3b0dcc90767250
Source dataset
uspto-grants-2002_07
Patent number
US06423840B1

Reaction notes

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