Hydrogen iodide → 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl) [1,4]diazepane hydriodic acid salt

HRID 2230500Notes

Reaction equation

HRID 2230500 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[N:15]1[CH2:21][CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[CH3:2].[IH:22]>C(O)C>[IH:22].[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[N:15]1[CH2:21][CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[CH3:2]

Participants

4

Reactant 2

HCID 24841Hydrogen iodideHCID 9984168Emedastine EP Impurity E

Product 1

HCID 865838874-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl) [1,4]diazepane hydriodic acid salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Alternately, combine 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane (18.42 g, 63.9 mmol), 57% hydriodic acid (8.30 mL), ethanol (80 mL) and stir. After 2.5 hours, cool to give a solid. Collect the solid by filtration, rinse with diethyl ether, and dry in vacuo to give the title compound.

Workup

  1. temperaturecool
  2. customto give a solid
  3. customCollect the solid
  4. filtrationby filtration
  5. washrinse with diethyl ether
  6. customdry in vacuo

Sources & evidence

ORD record
ord-55d9a0b1b8d3477e8a302f714cca778c
Source dataset
uspto-grants-2002_07
Patent number
US06423704B1

Reaction notes

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