反应详情

Combine 1-(3,4,5-trimethoxybenzoyl)-3-(3,4-dichlorophenyl)-3-(2-oxoethyl)pyrrolidine (0.51 g, 1.13 mmol), 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane (0.40 g, 1.36 mmol), and silica gel (about 2 g) in methanol (24 mL) and stir. After 3 days, add sodium cyanoborohydride (0.71 g, 11.3 mmol) and 3 Å molecular sieves (about 12 g) and stir under an inert atmosphere. After 18 hours, add a solution of 2 M sodium hydroxide and dichloromethane and stir. After 18 hours, filter, separate the layers in the filtrate, and extract the organic layer with brine. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to give a residue. Chromatograph the residue on silica gel eluting with 1/1 ethyl acetate/methanol to give, after drying in vacuo at 82° C., the title compound: mp; 55-65° C. Rf=0.36 (silica gel, 1/1 ethyl acetate/methanol). Elemental Analysis calculated for C38H47C12N5O5: C, 62.98; H, 6.54; N, 9.66; Found: C, 62.65; H, 6.65; N,9.51.

1. waitAfter 18 hours
2. stirringstir
3. waitAfter 18 hours
4. filtrationfilter
5. customseparate the layers in the filtrate
6. extractionextract the organic layer with brine
7. dry with materialDry the organic layer over Na2SO4
8. filtrationfilter
9. customevaporate in vacuo
10. customto give a residue
11. customafter drying in vacuo at 82° C.