反应详情

Combine methyl 2-chloro-3,4,5-trimethoxybenzoate (2.0 g, 7.8 mmol) and a 1 M aqueous solution of sodium hydroxide (100 mL, 100 mmol) in methanol (50 mL). After 6 hours, adjust the pH to about 2 using a 1 M aqueous hydrochloric acid solution and extract with dichloromethane. Dry the combined organic layers over MgSO4, filter, and concentrate in vacuo to give the title compound: Rf=0.81 (silica gel, 10% methanol/85% c.hloroform/5% acetic acid).

1. extractionextract with dichloromethane
2. dry with materialDry the combined organic layers over MgSO4
3. filtrationfilter
4. concentrationconcentrate in vacuo