Magnesium Bromide → 2-(2,2,2-Trifluoroethoxy)ethan-1-ol

HRID 2230663Notes

Reaction equation

HRID 2230663 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][CH2:5][CH2:6][O:7]C1CCCCO1.[Br-].[Mg+2].[Br-]>C(OCC)C>[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][CH2:5][CH2:6][OH:7]

Participants

4

Reactant 2

HCID 82241Magnesium BromideHCID 184646842-Tetrahydropyran-2-yloxyethyl 2,2,2-trifluoroethyl ether

Product 1

HCID 2558542-(2,2,2-Trifluoroethoxy)ethan-1-ol

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Combine 2-tetrahydropyran-2-yloxyethyl 2,2,2-trifluoroethyl ether (2 mmol) and magnesium bromide (6 mmol) in diethyl ether (10 mL). After 24 hours, extract with water and then brine. Dry the organic layer over Na2SO4, filter, and concentrate in vacuo to give 2-hydroxyethyl 2,2,2-trifluoroethyl ether.

Workup

  1. extractionextract with water
  2. dry with materialDry the organic layer over Na2SO4
  3. filtrationfilter
  4. concentrationconcentrate in vacuo

Sources & evidence

ORD record
ord-964f770646b844168629de189e4c828d
Source dataset
uspto-grants-2002_07
Patent number
US06423704B1

Reaction notes

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