HuagongsheHuagongshe Chemistry Print Report · For research reference only
Magnesium Bromide → 2-(2,2,2-Trifluoroethoxy)ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Magnesium Bromide | HCID 82241 | — |
| Reactant | 2-Tetrahydropyran-2-yloxyethyl 2,2,2-trifluoroethyl ether | HCID 18464684 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-(2,2,2-Trifluoroethoxy)ethan-1-ol | HCID 255854 | — |
Reaction Steps
Combine 2-tetrahydropyran-2-yloxyethyl 2,2,2-trifluoroethyl ether (2 mmol) and magnesium bromide (6 mmol) in diethyl ether (10 mL). After 24 hours, extract with water and then brine. Dry the organic layer over Na2SO4, filter, and concentrate in vacuo to give 2-hydroxyethyl 2,2,2-trifluoroethyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06423704B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-964f770646b844168629de189e4c828d |
| Source note | uspto-grants-2002_07 |